Pseudocoptisine chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氯化伪黄连碱是从延胡索块茎中分离出来的，具有抗炎和抗遗忘特性。 Pseudocoptisine Chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。

Pseudocoptisine chloride is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).(In Vitro):In RAW264.7 cells, Pseudocoptisine chloride (0, 60, 90 μM; 1 hour) inhibited LPS-induced NO production in a dose-dependent manner. Pseudocoptisine chloride reduced levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation. Pseudocoptisine chloride (30-90 μM; 1 hour) significantly reduced the LPS-induced TNF-α and IL-6 production and their mRNA expressions.(In Vivo):Pseudocoptisine chloride (2.0 mg/kg, p.o.) showed anti-amnesic activities on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) and significantly reverses cognitive impairments in mice by passive avoidance test.

Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.

The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test.

Isocoptisine chloride

Metabolic Enzyme/Protease

AChE

VHL

——

——

30044-78-1

355.77

C19H14ClNO4

>98% (HPLC)

In Vitro:?DMSO : 1 mg/mL (2.81 mM)

[N+]12=CC3=CC4=C(OCO4)C=C3C=C1C5=CC6=C(OCO6)C=C5CC2.[Cl-]

——

(-20℃)

With Ice Pack

≥ 2 years